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范江霖

范江霖 简历

西安医学院,基础医学部,教授

教育经历(从大学本科开始,按时间倒序排序;请列出攻读研究生学位阶段导

师姓名):

1.1988/41992/3 佐贺医科大学, 病理学, 博士, 导师:渡边照男

2.1983/71986/7 中国医科大学, 病理解剖学, 硕士, 导师:陈铁镇

3.1978/31983/7 延边大学, 医学院, 学士, 导师:

科研与学术工作经历(按时间倒序排序;如为在站博士后研究人员或曾进入博士后流动站(或工作站)从事研究,请列出合作导师姓名):

1.2015/3-至今,西安医学院,病理解剖教研室,教授

2.2006/3-至今,日本山梨大学,医学系,教授

3.2001/1-2006/3,日本筑波大学,医学系,副教授

4.1995/6-2001/1,日本筑波大学,医学系,讲师

主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

1. 范江霖,陕西省自然科学基金重点项目,2017JZ028,利用转基因和基因敲除家兔研究动脉粥样硬化发生机制,起止时间: 2017-01-01至2019-12-31,10万,在研,主持

2. 范江霖,国家自然科学基金面上项目,81770457,利用基因敲入家兔研究载脂蛋白A-II在动脉粥样硬化发生中的作用,起止时间:2018.01-2021.12,83万,在研,主持

代表性研究成果和学术奖励情况(每项均按时间倒序排序)

一、期刊论文

1.第一作者论文

(1)   Fan, Jianglin(#)(*)Kitajima, ShujiWatanabe, TeruoXu, JieZhangJifengLiu, EnqiChen, Y EugeneRabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.Pharmacol Ther2015146104-119

(2)   Fan, Jianglin(#)(*)Watanabe, TeruoTransgenic rabbits as therapeutic protein bioreactors and human disease models.Pharmacol Ther2003993):261-282

(3)   Fan, Jianglin(#)(*)Watanabe, TeruoInflammatory reactions in the pathogenesis of atherosclerosisJ Atheroscler Thromb2003102):63-71

2.通讯作者论文(勿与第一作者论文重复)

(1)   Li, ShenWang, Yan-ningNiimi, ManabuNing, BoChen, YajieKang, DedongWang, ZiyunYu, QiWaqar, Ahmed BilalLiu, EnqiZhang, JifengShiomi, MasashiChen, Y. EugeneJianglin Fan(*)Angiotensin II destabilizes coronaryplaques in WHHL rabbitsArterioscler Thromb Vasc Biol in press 2016

(2)   Niimi, Manabu(#)Yang, DongshanKitajima, ShujiNing, BoWang, ChuanLi, ShenLiu, EnqiZhang, JifengEugene Chen, YFan, Jianglin(*)ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.Atherosclerosis2016245187-193

(3)   Ning, BoWang, XiaoyanYu, YingWaqar, Ahmed BilalYu, QiKoike, TomonariShiomi, MasashiLiu, EnqiWang, YifeiFan, Jianglin(*)High-fruct ose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits.Nutr Metab (Lond)20151230-30

(4)   Fang, Chao(#)Ning, BoWaqar, Ahmed BilalNiimi, ManabuLi, ShenSatoh, KaneoShiomi, MasashiYe, TingDong, SijunFan, Jianglin(*)Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits.Journal of Applied Toxicology2015359):1058-1070

(5)   Yu, Qi(#)Liu, ZhengcaoWaqar, Ahmed BilalNing, BoYang, XianghongShiomi, MasashiGraham, Mark JCrooke, Rosanne MLiu, EnqiDong, SijunFan, Jianglin(*)Effects of antisense oligonucleotides against C-reactive protein on the development of atherosclerosis in WHHL rabbits.Mediators Inflamm20142014979132-979132

(6)   Torzewski, Michael(#)Waqar, Ahmed BilalAnimal,Fan, Jianglin(*), models of C-reactive protein.Mediators Inflamm20142014683598-683598

(7)   Li, ShenLiang, JingyanNiimi, ManabuBilal Waqar, AhmedKang, DedongKoike, TomonariWang, YinggeShiomi, MasashiFan, Jianglin(*)Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits.J Atheroscler Thromb2014217):648-658

(8)  Niimi, Manabu(#)Keyamura, YukaNozako, MasanoriKoyama, TakashiKohashi, MasayukiYasufuku, ReikoYoshikawa, TomohiroFan, Jianglin(*)Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits.Lipids in Health and Disease201312166-166

(9)  Wang, Yao(#)Niimi, ManabuNishijima, KazutoshiWaqar, Ahmed BilalYu, YingKoike, TomonariKitajima, ShujiLiu, EnqiInoue, TomohiroKohashi, MasayukiKeyamura, YukaYoshikawa, TomohiroZhang, JifengMa, LorettaZha, XiaohuiWatanabe, TeruoAsada, YujiroChen, Y EugeneFan, Jianglin(*)Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits.Arteriosclerosis, Thrombosis, and Vascular Biology2013332):224-231

(10)  Wang, Ziyun(#)Li, ShenSun, LidanLiu, ZhenmingFan, Jianglin(*)Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors.PLos One201388):e72146-e72146

(11)  Zhang, Jifeng(#)Yu, YingNakamura, KaeKoike, TomonariWaqar, 

Ahmed BilalZhang, XiaoweiLiu, EnqiNishijima, KazutoshiKitajima, ShujiShiomi, MasashiQi, ZhongxiaYu, JingweiGraham, Mark JCrooke, Rosanne MIshida, TatsuroHirata, Ken-IchiHurt-Camejo, EvaChen, Y EugeneFan, Jianglin(*)Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.J Atheroscler Thromb2012193):213-226

(12)  Waqar, Ahmed Bilal(#)Koike, TomonariYu, YingInoue, TomohiroAoki, TadashiLiu, EnqiFan, Jianglin(*)High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits.Atherosclerosis20102131):148-155

(13)  Koike, Tomonari(#)Kitajima, ShujiYu, YingNishijima, KazutoshiZhang, JifengOzaki, YukioMorimoto, MasatoshiWatanabe, TeruoBhakdi, SucharitAsada, YujiroChen, Y EugeneFan, Jianglin(*)Human C-reactive protein does not promote atherosclerosis in transgenic rabbits.Circulation200912021):2088-2094

(14)  Koike, Tomonari(#)Kitajima, ShujiYu, YingLi, YingNishijima, KazutoshiLiu, EnqiSun, HuijunWaqar, Ahmed BilalShibata, NobumitsuInoue, TomorihoWang, YaoZhang, BoKobayashi, JunjiMorimoto, MasatoshiSaku, KeijiroWatanabe, TeruoFan, Jianglin(*)Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia.Arterioscler Thromb Vasc Biol20092912):2047-2053

(15)  Yu, Ying(#)Koike, TomonariKitajima, ShujiLiu, EnqiMorimoto, MasatoshiShiomi, MasashiHatakeyama, KintaAsada, YujiroWang, Ke-YongSasaguri, YasuyukiWatanabe, TeruoFan, Jianglin(*)Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions.Histol Histopathol20082312):1503-1516

(16)  Shiomi, Masashi(#)(*)Unstable coronary plaques and Fan, Jianglin(*),cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries.Current Opinion in Lipidology2008196):631-636

(17)  Kitajima, Shuji(#)Jin, YingjiKoike, TomonariYu, YingLiu, EnqiShiomi, MasashiMarcovina, Santica MMorimoto, MasatoshiWatanabe, TeruoFan, Jianglin(*)Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits.Atherosclerosis20071932):269-276

(18)  Liu, Enqi(#)Morimoto, MasatoshiKitajima, ShujiKoike, TomonariYu, YingShiiki, HideoNagata, MichioWatanabe, TeruoFan, Jianglin(*)Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions.Journal of the American Society of Nephrology2007187):2094-2104

(19)  Liang, Jingyan(#)Liu, EnqiYu, YingKitajima, ShujiKoike, TomonariJin, YingjiMorimoto, MasatoshiHatakeyama, KintaAsada, YujiroWatanabe, TeruoSasaguri, YasuyukiWatanabe, ShigeyukiFan, Jianglin(*)Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.Circulation200611316):1993-2001

(20)  Kitajima, Shuji(#)Liu, EnqiMorimoto, MasatoshiKoike, TomonariYu, YingWatanabe, TeruoImagawa, ShigehikoFan, Jianglin(*)Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver: a new model for Kasabach-Merritt syndrome.Laboratory Investigation20058512):1517-1527

(21)  Sun, Huijun(#)Koike, TomonariIchikawa, TomonagaHatakeyama, KintaShiomi, MasashiZhang, BoKitajima, ShujiMorimoto, MasatoshiWatanabe, TeruoAsada, YujiroChen, Yuqing EFan, Jianglin(*)Creactive protein in atherosclerotic lesions: its origin and pathophysiological significance.American Journal Of Pathology20051674):1139-1148

(22)  Ichikawa, Tomonaga(#)Liang, JingyanKitajima, ShujiKoike, TomonariWang, XiaofeiSun, HuijunMorimoto, MasatoshiShikama, HisatakaWatanabe, TeruoYamada, NobuhiroFan, Jianglin(*)Macrophage-deriv ed lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits.Atherosclerosis20051791):87-95

(23)  Koike, Tomonari(#)Liang, JingyanWang, XiaofeiIchikawa, TomonagaShiomi, MasashiSun, HuijunWatanabe, TeruoLiu, GeorgeFan, Jianglin(*)Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.Cardiovascular Research2005652):524-534

(24)  Liu, Enqi(#)Kitajima, ShujiHigaki, YasukiMorimoto, MasatoshiSun, HuijunWatanabe, TeruoYamada, NobuhiroFan, Jianglin(*)High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.Metabolism-Clinical and Experimental2005541):132-138

(25)  Wang, Xiaofei(#)Liang, JingyanKoike, TomonariSun, HuijunIchikawa, TomonagaKitajima, ShujiMorimoto, MasatoshiShikama, HisatakaWatanabe, TeruoSasaguri, YasuyukiFan, Jianglin(*)Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.American Journal Of  Pathology20041654):1375-1383

(26)  Koike, Tomonari(#)Liang, JingyanWang, XiaofeiIchikawa, TomonagaShiomi, MasashiLiu, GeorgeSun, HuijunKitajima, ShujiMorimoto, MasatoshiWatanabe, TeruoYamada, NobuhiroFan, Jianglin(*)Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesityJournal of Biological Chemistry20042799):7521-7529

3.既非第一作者又非通讯作者论文

(1)  Zhao, Sihai(#)Li, YafengGao, ShoucuiWang, XiaojingSun, LijingCheng, DaxingBai, LiangGuan, HuaWang, RongFan, JianglinLiu,EnqiAutocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits.Biomed Research International20152015843959-843959

(2)  Yang, Dongshan(#)Xu, JieZhu, Tianqing, Lai,Fan, Jianglin,LiangxueZhang, JifengChen, Y EugeneEffective gene targeting in rabbits using RNA-guided Cas9 nucleases.J Mol Cell Biol201461):97-99

(3)  Yang, Dongshan(#)Zhang, JifengXu, JieZhu, TianqingFan, YanboFan, JianglinChen, Y EugeneProduction of apolipoprotein C-III knockout rabbits using zinc finger nucleases.J Vis Exp2013,(81):e50957-e50957

(4)  Ding, Yinyuan(#)Wang, YuhuiZhu, HongFan, Jianglin, Yu, LiqingLiu, GeorgeLiu, EnqiHypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII.Transgenic Research2011204):867-875

(5)  Pravenec, Michal(#)(*)Kajiya, TakashiZidek, VaclavLanda, VladimirMlejnek, PetrSimakova, MiroslavaSilhavy, JanMalinska, HanaOliyarnyk, OlenaKazdova, LudmilaFan, JianglinWang, JiamingKurtz, Theodore WEffects of human C-reactive protein on pathogenesis of features of the metabolic syndrome.Hypertension2011574):731-737

(6)  Shiomi, Masashi(#)(*)Ito, TakashiYamada, SatoshiKawashima, SeinosukeFan, JianglinDevelopment of an animal model for spontaneous myocardial infarction (WHHLMI rabbit).Arterioscler Thromb Vasc Biol2003237):1239-1244

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